The End of Evidence Based Medicine and The Rise of Medical Propaganda

Evidence Based Medicine

By Dr. Farrah-Arsenia Agustin-Bunch and Dr. Jason Fung

The idea that Evidence Based Medicine (EBM) is what makes Conventional Medicine “highly credible and trustworthy” is probably going to be a thing of the past very soon. I say this because clinical research that is published and peer-reviewed now is fast becoming a property of Big Pharma and highly influenced by them. If scientific research is going to be owned and manipulated by Big Pharma, then why do we still have to do clinical trials of drugs today?

The issue has become so rampant today that I quote two former editors of The New England Journal of Medicine (NEJM) who had something to say about this:

“It is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgment of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly and reluctantly over my two decades as an editor.” — Dr. Marcia Angell, former editor of the NEJM, 2009

“The medical profession is being bought by the pharmaceutical industry, not only in terms of the practice of medicine, but also in terms of teaching and research. The academic institutions of this country are allowing themselves to be the paid agents of the pharmaceutical industry. I think it’s disgraceful.” – Dr. Relman, former editor of the NEJM, 2002

If two of the most trusted editors of the oldest and most prestigious medical journal in the U.S. feel this way about evidence based medicine, then should we be changing our mindset instead that our “evidence based medicine”, which thrived on the generation of “unbiased, medical evidence” is now more of “medical propaganda”?

Merriam-Webster defines Propaganda as “the spreading of ideas, information or rumor for the purpose of helping or injuring an institution, a cause, or a person; ideas, facts, or allegations spread deliberately to further one’s cause or to damage an opposing cause”. However, an important component of propaganda, as explained by Joseph Goebbels, a well-known promoter of the Nazi propaganda machine during World War II, is that if you “keep telling a lie that is big enough and keep repeating it, people will eventually come to believe it.”

Therefore, it follows that successful medical propaganda depends on suppressing not only concern about the truth but also the truth itself. The group wanting to promote a big lie must also “use all of its powers to repress dissent, for the truth is the mortal enemy of the lie.”

I assert this last point about medical propaganda, for I have been on the receiving end of some nasty propaganda about the legitimacy and effectivity of the work we I have done, that is, using “all-natural, plant-based, and organic remedies and treatments” for Cancer and other debilitating, chronic diseases. I say this wholeheartedly because I believe that my work is based on “sound, scientific, and verifiable” evidence based on clinical trials that I and my colleagues have done for the past 16 years.

And like the point I raised earlier about medical propaganda, you can use so-called “evidence-based medicine” and hurl it at someone, attacking them for coming out with “alternative treatments” that are generating effective and repeatable medical results so that your opponents can justify the “effectiveness” and “legitimacy” of their product and practice. But we know too well that the evidence can be manipulated in the favor of the propagandist. And like what the Nazi propagandist Joseph Goebbels said before, to promote a “big lie”, one must use all of their powers to repress any dissenting voice, no matter how right or reasonable that voice is, for “the truth is the mortal enemy of the lie”.

Ways by Which Evidence Based Medicine is Manipulated

As everyone knows in the medical and health industries, if the evidence base is false or corrupted, then the entire structure is false as well. You can find them everywhere in the medical and health industries – research that is almost always paid for by pharmaceutical companies. Studies that are done by industry that yield only positive results while the negative findings are downplayed, or otherwise promoted only in a positive light. And the editors of the medical journals that print all these questionable “evidence-based studies” are slowly realizing that the work they’ve painstakingly made and guarded to reveal the truth had been slowly eroding under the watchful eyes of the medical propagandists.

Here are some ways by which our evidence based medicine has been corrupted by Big Pharma, as propounded by a fellow medical doctor, Dr. Jason Fung in his article published in

Selective Publication — Negative trials (those that show no benefit for the drugs) are likely to be suppressed. For example, in the case of antidepressants, 36/37 studies that were favorable to drugs were published. But of the studies not favorable to drugs, a paltry 3/36 were published. Selective publication of positive (for the drug company) results means that a review of the literature would suggest that 94% of studies favor drugs where in truth, only 51% were actually positive. Suppose you know that your stockbroker publishes all his winning trades, but suppresses all his losing trades. Would you trust him with your money? But yet, we trust EBM with our lives, even though the same thing is happening.

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Let’s look at the graph of a number of trials completed versus those that were published. In 2008, the company Sanofi completed 92 studies but only a piddly 14 were published. Who gets to decide which gets published and which does not? Right. Sanofi. Which ones do you think will be published? The ones that favor its drugs, or the ones that prove their drugs do not work? Right. Keep in mind that this is the only rational course of action for Sanofi, or any other company to pursue. It’s idiotic to publish data that harms yourself. It’s financial suicide. So this sort of rational behavior will happen now, and it will not stop in the future. But knowing this, why do we still believe the evidence based medicine, when the evidence base is completely biased? An outside observer, only looking at all published data, will conclude that the drugs are far, far more effective than they are in reality. Yet, if you point this out in academic circles, people label you a quack, who does not ‘believe the evidence’.


Rigging of Outcomes — Or consider the example of registration of primary outcomes. Prior to the year 2000, companies doing trials did not need to declare what end points they measured. So they measure many different endpoints and simply figured out which one looked best and then declared the trial a success. Kind of like tossing a coin, looking at which one comes up more, and saying that they were backing the winning side. If you measured enough outcomes, something was bound to come up positive.

In 2000, the government moved to stop these shenanigans. They required companies to register what they were measuring ahead of time. Prior to 2000, 57% of trials showed a positive result. After 2000, a paltry 8% showed good results. More evidence of the evidence base being completely corrupted by commercial interest, and the academic physicians who were getting rich on it tacitly allowing corruption because they know that you don’t bite the hand that feeds you

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‘Advertorials’ — Or this example of a review paper in the NEJM that fracture rates caused by the lucrative bisphosphonate drugs were “very rare”. Not only did the drug companies pay lots of consulting fees to the doctors, three of the authors of this review were full time employees! To allow an advertorial to be published as the best scientific fact is scandalous. Doctors, trusting the NEJM to publish quality, unbiased advice have no idea that this review article is pure advertising. Yet, we still consider the NEJM to be the very pinnacle of evidence based medicine. Instead, as all the editors of the journals sadly recognize, it has become lucre-based publishing. Mo money = better results.

Money from Reprints — The reasons for this problem is obvious to all — it’s insanely profitable for journals to take money from Big Pharma. Journals want to be read. So they all try to get a high Impact Factor (IF). To do this, you need to get cited by other authors. And nothing boosts ratings like a blockbuster produced by Big Pharma. They have the contacts and the sales force to make any study a landmark. A less obvious benefit is the fees that are generated by Big Pharma purchasing articles for reprint. If a company publishes an article in the NEJM, they may order several hundred thousand copies of the article to be distributed to unsuspecting doctors everywhere. These fees are not trivial. The NEJM publisher Massachusetts Medical Society gets 23% of its income from reprints. The Lancet — 41%. The American Medical Association — a gut busting 53%. No wonder these journals are ready to sell their readers (ordinary physicians) down the river. It pays. Who needs journalistic ethics when there’s a Mercedes in the driveway? Mo money, baby. Mo money.

Bribery of Journal Editors — A recent study by Liu et al in the BMJ shed more light on the problem of crooked journals. Crooked journal editors. Editors play a crucial role in determining the scientific dialogue by deciding which manuscripts are published. They determine who the peer reviewers are. Using the Open Payments database, they looked at how much money the editors of the most influential journals in the world were taking from industry sources. This includes ‘research’ payments, which are largely unregulated. As mention previously, much ‘research’ consists of going to meetings in exotic locale. It funny how many conferences are held in beautiful European cities like Barcelona, and how few are done in brutally cold Quebec City.

Of all journal editors that could be assessed, 50.6% were on the take. The average payment in 2014 was $27,564. Each. This does not include an average $37, 330 given for “research” payments. Other particularly corrupt journals include:

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This is slightly horrifying. Each editor of the Journal of the American College of Cardiology received, on average $475,072 personally and another $119,407 for ‘research’. With 35 editors, that’s about $15 million in bribes to doctors. No wonder the JACC loves drugs and devices. It pays the private school bills. Mo money = we’ll publish your crooked studies for you. Mo money, baby, mo money.

Publication Bias — The evidence base that EBM depends upon is completely biased. Some people think I’m really anti-Pharma, but this is not really true. Big Pharma companies have a duty to their shareholders to make money. They have no duty to patients. On the other hand, doctors have a duty to patients. Universities have a duty to remain unbiased.

It is the failure of doctors and universities to keep their greedy paws out of the corrupting influence of Big Pharma money that is the problem. If Big Pharma is allowed to spend lots of $$$ paying off doctors and universities and professors, then it should do so to maximize profits. That is their mission statement. Doctors love to blame Big Pharma companies because it takes peoples’ gaze off the real problem — lots of doctors taking $$$ from anybody who will pay. The pharma industry is not the problem. Bribery of university doctors is the problem — one that is easily fixed if the political will exists.

Consider this study. Looking at studies in the field of neurodegenerative disease, researchers looked at all the studies that were started but never finished or never published. Approximately 28% of studies never made it to the finish line. That’s a problem. If all the studies that don’t look promising for drug candidates are not published, then it appears that the drugs are way more effective than they really are. But the published ‘evidence base’ would falsely support the drug. Indeed, Pharma sponsored trials were 5 times more likely to be unpublished.

Imagine you have a coin flipping contest. Suppose a player called ‘Big Pharma” chooses heads, and also pays the coin flipper. Every time the coin flipper pulls up tails, the results don’t count. Every time it comes up heads, it counts. This happens 28% of the time. Now, instead of a 50/50 split of heads and tails, it’s more like a 66/34 split of heads/tails. So the ‘evidence based medicine’ lover claims that heads are far more likely to come up than tails, and castigates people who don’t believe the results as ‘anti-science’.

Evidence based medicine depends entirely upon having a reliable base of evidence (studies). If the evidence base is tampered with, and paid for, then EBM as a science is completely useless. Indeed, the very editors whose entire careers have been EBM have now discovered it to be worthless. Does the CEO of Phillip Morris (maker of Marlboro cigarettes) smoke? That tells you all you need to know about the health risks. Do the editors of the NEJM and the Lancet believe EBM anymore? Not at all. So neither should we. We can’t believe evidence based medicine until the evidence has been cleaned up from the corrupting influence of commercial interests.

Financial conflicts of interest (COI), also known as gifts to doctors, is a well-accepted practice. A national survey in the New England Journal of Medicine in 2007 shows that 94% of physicians had ties to the pharmaceutical industry. This gravy train only rides in one direction. From Big Pharma to the wallets of doctors. Sure Big Pharma can simply pay doctors directly, and it does plenty of that. It’s no surprise that medical students with more exposure to pharmaceutical reps develop a more positive attitude towards them. Many medical schools have limited exposure of medical students in response, but declined to get off the gravy train themselves. There is a simple relationship between how prominent a physician is (more articles published — almost always academic doctors and professors) and how much money they take from Big Pharma. Mo prominent = mo money. Further, there is a ‘clear and strong link’ between taking industry money and minimizing the risk of side effects of medications. What, you thought people teach at prestigious institutions like universities for the good of mankind? Maybe that’s why they went there, but that’s not why they stay. They came for the science. They stayed for the money.

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So in summary, here is the list of all the problems that plague Evidence Based Medicine now:

  1. Selective Publication
  2. Rigged outcomes
  3. Advertorials
  4. Reprint Revenues
  5. Bribery of Journal Editors
  6. Publication Bias
  7. Financial Conflicts of Interests

As medical doctors and health practitioners, we need to stop these shenanigans of buying off doctors, universities, and medical institutions by Big Pharma. We need to present only the truth and nothing but the unblemished, un-manipulated TRUTH. Or we fall short of the principles that we adhere to under the Hippocratic Oath.

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